2025 · Article · Open Access
Optimal drug management and drug inventory control can minimize costs and the number of orders in the next planning period. The purpose of this study was to evaluate drug management in the Pharmacy Installation of Harapan Insan Sendawar Hospital with SWOT analysis improvement strategies. The research design was descriptive based on retrospective and concurrent data. All quantitative data were compared with the indicators of The Depkes RI(2008), WHO (1993),and Pudjaningsih in Satibi (2022). Furthermore, qualitative analysis was carried out with a SWOT approach as an alternative improvement strategy in the Pharmacy Installation based on quantitative data output and internal capital and external influences. The results of the study that meet the standards are: the level of drug availability (15.6 months) and the average prescription service time (non-compoundedprescription 23.37 minutes & prescription 39.8 minutes). Results that did not meet the standard were: percentage of stock card matches with drugs (94.73%), inventory turnover ratio (2.22 times), percentage of expired drugs (4.7%), percentage of dead stock (8.97%), number of drug items per prescription sheet (3.57 items), percentage of generic drug prescriptions (76.25%).SWOT analysis of the pharmacy installation falls within the first quadrant, namely focusing on development, improving services andestablishing cooperation.The conclusion drawn is that pharmacy installations can adopt aggressive strategies by enhancing the development of management information systems to optimize inventory control.
2025 · Article · Open Access
Parkinson's disease (PD) is a severe neurodegenerative disorder, that causes progressive motor issues from the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNpc). Purple yam (Dioscorea alata), rich in anthocyanins, shows promise as a natural antioxidant and neuroprotectant. This study investigated the antiparkinsonian effects of D. alata extract on dopamine levels and brain microscopic features in a haloperidol-induced PD mouse model. Thirty-five male mice were randomly allocated into seven groups: normal (CMC-Na and aqua pro injection), haloperidol-induced negative control (CMC-Na), positive control (levodopa 39 mg/kgBW), curcumin (200 mg/kgBW), and D. alata extract-treated groups (100, 200, and 400 mg/kgBW). Treatments were administered daily for seven days. On day 8, all groups, except the normal control, received an intraperitoneal injection of haloperidol (2 mg/kgBW) to induce Parkinsonism. Three hours post-haloperidol injection, dopamine levels were measured from orbital vein blood. Subsequently, brains were harvested for histological examination of the SNpc using Toluidine blue staining. Data were statistically analyzed using one-way ANOVA followed by LSD post-hoc tests. The 400 mg/kgBW dose of D. alata extracts significantly increased dopamine levels (p 0.05) compared to the negative control group. Microscopic analysis of the SNpc in mice treated with 400 mg/kgBW extract revealed preserved, dark, and solid neuronal morphology, with significantly higher scoring results (p 0.05) when compared to the levodopatreated group. These findings suggest that D. alata extract, particularly at a dose of 400 mg/kgBW, exhibits potential antiparkinsonian activity by elevating dopamine levels and mitigating dopaminergic neuronal damage in a haloperidolinduced PD mouse model.
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
2025 · Article · Open Access
Kepatuhan pasien berpengaruh terhadap keberhasilan suatu pengobatan. Kegagalan pasien hipertensi mencapai target penurunan darah seringkali disebabkan pasien tidak meminum obat yang diresepkan. Penelitian ini bertujuan untuk mengetahui kepatuhan minum obat pada pasien hipertensi di Puskesmas Muara Wis. Penelitian dilakukan dengan metode Cohort study menggunakan alat kuesioner MMAS-8 dan penghitungan jumlah obat yang belum diminum pasien (pill count). Sampel yang dipilih adalah pasien hipertensi di Puskesmas Muara Wis, telah meminum obat antipertensi minimal 12 bulan, tidak memiliki penyakit komplikasi, dan bersedia menjadi responden. Data dianalisis secara deskriptif. Hasil penelitian menunjukkan pasien memiliki tingkat kepatuhan minum obat yang rendah 53,33%, kepatuhan sedang 33,33%, kepatuhan tinggi 13,33%. Berdasarkan metode pill count, 50,00% pasien memiliki tingkat kepatuhan rendah, 30,00% tingkat kepatuhan sedang, dan 20,00% tingkat kepatuhan tinggi. Uji korelasi spearman rank menunjukan bahwa bahwa ada hubungan antara antara tingkat kepatuhan pasien dari metode kuesioner dengan hasil perhitungan pill count. Hal ini menunjukkan bahwa kepatuhan pasien meminum obat antihipertensi di puskesmas Muara Wis masih rendah. Disarankan Puskesmas Muara Wis lebih aktif melakukan konseling kepada pasien untuk meningkatkan motivasi pasien.
2025 · Article · Open Access
We are using soap to remove dirt and bacteria in the skin. Traditionally, soap is made from vegetable oils and lye with simple home tools like pan and stove. Materials for handmade soap is not expensive and easily available, but it gives us a luxury bath. The reaction between fatty acid and lye in soap produces glycerin, a good humectant, to keep our skin supple and moist. Commercial soap manufacturer make it a practice to remove the glycerin that is produces during the saponification process. Hence, handmade soap does not dried out skin, like the commercial soap product. This activity aimed to (1) sharing information about PKK community in Gunung Kelua RT.37, and (2) to teach the community how to make a handmade soap with cheap materials that easily available. This activity used dialog method to discuss the benefit of soaps, soap materials, and sop-making practice. The practice of making soap is demonstrated in front of audience, and many audiences had a hand in practice. This activity then evaluated. The result is all audience has understood how to make soap and were able to practice soap-making.
2025 · Article · Open Access
Henslowia frutescens is a semi-parasitic plant, although considered harmful, it has medicinal and cosmetic potential. This plant has secondary metabolite compounds, namely phenolic compounds, flavonoids, saponins, tannins, and steroids which have high antioxidant activity. The purpose of this study was to determine the sunscreen activity of the ethanol extract of Henslowia frutescens based on the in vitro SPF (Sun Protecting Factor) value and to determine its antioxidant activity. The research stages included sampling, sampling, maceration extraction with 95% ethanol, yield calculation, phytochemical screening, sunscreen activity test based on SPF value, and antioxidant activity test. Data analysis was carried out descriptively based on the measurement results processed according to the calculation formula. The results showed that the sunscreen activity of the ethanol extract of Henslowia frutescens based on the in vitro SPF value was 14.57 - 25.20 with moderate protection category. The antioxidant activity of the ethanol extract of Henslowia frutescens showed a very strong category with an IC value of 22.82 ± 1.33.
2025 · Article · Open Access
Lemak biji tengkawang (Shorea mecistopteryxRidley) merupakan salah satu tumbuhan khas Kalimantan yang memiliki karakteristik fisik menyerupai lemak kakao. Kandungan lemak nabati yang tinggipada lemak biji tengkawang, sepertiasam oleat sebesar 55,95%, asam palmitat 14,02%, miristat 0,05%, dan stearat 0,05%mendorong peneliti untuk melakukan penelitiandengan memanfaatkan lemak biji tengkawang sebagai basis dalampembuatan sediaan kosmetika,seperti losion. Penelitianinidilakukan dengan mengkombinasi lemak biji tengkawang danlemak kakaosebagai basis losion. Kombinasi ini bertujuan untuk mengetahui karakteristik fisik losion yang dihasilkan dari perbedaankosentrasi.Karakteristik fisik losion diketahui melalui beberapa evaluasi, yaitu organoleptis, homogenitas, viskositas, pH, daya lekat, penyusutan bobot, dan stabilitassecara mekanik. Berdasarkan evaluasi yangdilakukan diperoleh data yang menunjukkan adanya pengaruh yang disebabkan oleh perbedaan kosentrasi basis terhadap karakteristik fisik losion. Perbedaan karakteristik fisik yang mencolok terutama terlihat pada nilai viskositasyang menunjukkan formula I1485,55 cp, formula II 3408,88 cp, formula III 2017,77 cp, dan formula IV 3314,44 cp. Viskositas meningkat seiring lama waktu penyimpanan dan ini berbanding lurus dengan kemampuan daya lekat losion
2025 · Article · Open Access
Fish oil is one of the nutrients of choice to overcome the prevalence of stunting. Made from Pangasius micronemes,
Patin and Haruan fish oil functions as a source of omega-3 or omega-6 fatty acids, in overcoming stunting. Although
commercial fish oil production is on the rise, not all products meet International Fish Oil Standards. The study of the
chemical properties and fatty acid profile of catfish and Haruan fish oil used experimental methods involving the
extraction of fish flesh based on the dry pressing method to produce crude oil and pure oil. Analysis parameters
include chemical properties (free fatty acids, peroxide, iodine, and saponification), and linear fatty acid profile. The
fish oil RSA activity test was carried out with DPPH. Catfish oil yield 7.80%±0.15%, free fatty acids 1.86±0.02%,
peroxide 6.66±0.26meq/kg sample, iodine 82.97±1.85g/100 g sample, and saponification 199.81±3.86 mg KOH/g.
Analysis of the total fatty acid concentration of catfish oil, including saturated fatty acids (14.65%), unsaturated fatty
acids (85.31%), omega-3 (3.66%), omega-6 (16.18%), and omega-9 (5.82%) and haruan fish oil with a yield of
1.82±0.13%, complete free fatty acids 1.89±0.04%, peroxide 7.13±0.09 meq/kg sample, iodine 111.57±9.4 g/100 g
sample, and saponification value 193.28±5.24 mg KOH/g. The results showed that the total fatty acid concentration
of haruan fish oil showed saturated fatty acids (23.65%), unsaturated fatty acids (21.31%), and omega-3 (8.3%). The
RSA DPPH results were 20.94 ± 1.52% for catfish oil and 23.08% ± 0.50% for haruan fish oil. Based on the results
of research, haruan and catfish oil have the potential active ingredients in emulsion preparation to overcome stunting.
